Interaction Checker

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Prescribing Resources

We have produced a series of printable materials in PDF format to aid prescribing.

Interpreting the Interaction Checker flowchart demonstrating how to use the drug interaction checker to manage drug-drug interactions.

Interaction Summary Tables provide an overview of interactions between hepatology drugs and the comedications listed in the interaction checker.

Treatment Selectors show interactions between key HCV DAAs and drugs used to treat a range of common comorbidities or specific patient populations.

Fact Sheets contain information on the pharmacokinetics, metabolism and disposition of drugs used to treat viral hepatitis and have been collated from product labels and published literature on licensed doses (unless otherwise stated). Please click on the headings below to see the full range of resources within each section.

Interpreting the Interaction Checker

Interpreting the Liverpool HEP Interactions Checker

Updated December 2019

Interaction Summary Tables

Interactions With HBV Treatment

Updated June 2022

Interactions With HCC Treatment

Updated June 2022

Interactions With HCV DAAs and Ribavirin

Updated June 2022

Interactions With HDV Treatment

Updated June 2022

Interactions With PBC Treatment

Updated June 2022

Treatment Selectors

Acid Reducing Agents

Updated May 2018

Anticoagulants & Antiplatelets

Updated May 2018

Antiepileptics

Updated June 2022

Antipsychotics/Neuroleptics

Updated May 2021

Recreational Drugs

Updated June 2022

HCV DAA PK Fact Sheets

Daclatasvir

Updated March 2016

Dasabuvir

Updated March 2016

Elbasvir

Updated March 2016

Glecaprevir

Updated April 2019

Grazoprevir

Updated March 2016

Ledipasvir

Updated March 2016

Ombitasvir

Updated March 2016

Paritaprevir

Updated March 2016

Pibrentasvir

Updated April 2019

Simeprevir

Updated March 2016

Sofosbuvir

Updated March 2016

Velpatasvir

Updated April 2019

Voxilaprevir

Updated April 2019

Hepatitis Nucleoside/tide Analogue PK Fact Sheets

Adefovir

Updated March 2016

Entecavir

Updated March 2016

Lamivudine

Updated March 2016

Ribavirin

Updated March 2016

Telbivudine

Updated March 2016

Tenofovir alafenamide

Updated April 2019

Tenofovir-DF

Updated March 2016

PBC Agents PK Fact Sheets

Obeticholic Acid

Updated July 2019

Ursodeoxycholic acid

Updated August 2019

HCC Therapies PK Fact Sheets

Lenvatinib

Updated February 2021

Pembrolizumab

Updated November 2019

Regorafenib

Updated August 2021

Sorafenib

Updated February 2021

HDV Treatments PK Fact Sheets

Bulevirtide PK Fact Sheet

Updated September 2021

External Resources

Drugs in liver cirrhosis - Health Base Foundation

Updated December 2021
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