Coadministration of emtricitabine (200 mg once daily with efavirenz and tenofovir-DF) and sofosbuvir/velpatasvir (400/100 mg once daily) increased sofosbuvir Cmax by 38% but decreased AUC by 3%; Cmax and AUC of GS-331007 decreased by 14% and 10%, but Cmin increased by 1%; velpatasvir Cmax, AUC and Cmin decreased by 47%, 53% and 57%, respectively (n=14). Emtricitabine Cmax, AUC and Cmin increased by 7%, 7% and 10%, respectively (n=15).
Coadministration of emtricitabine (200 mg once daily with elvitegravir/cobicistat and tenofovir-DF) and sofosbuvir/velpatasvir (400/100 mg once daily) was studied in 24 subjects. Cmax and AUC of sofosbuvir increased by 1% and 24%; Cmax, AUC and Cmin of GS-331007 increased by 13%, 35% and 45% respectively. Velpatasvir Cmax, AUC and Cmin increased by 5%, 19% and 37%, respectively. Emtricitabine Cmax, AUC and Cmin increased by 2%, 1% and 6%, respectively.
Coadministration of emtricitabine (200 mg once daily with elvitegravir/cobicistat and tenofovir alafenamide) and sofosbuvir/velpatasvir (400/100 mg once daily) was studied in 23 subjects. Cmax and AUC of sofosbuvir increased by 23% and 37%; Cmax, AUC and Cmin of GS-331007 increased by 29%, 48% and 58% respectively. Velpatasvir Cmax, AUC and Cmin increased by 30%, 50% and 60%, respectively. Emtricitabine Cmax, AUC and Cmin increased by 2%, 1% and 2%, respectively (n=24).
Coadministration of emtricitabine (200 mg once daily with rilpivirine and tenofovir-DF) and sofosbuvir/velpatasvir (400/100 mg once daily) was studied in 24 subjects. Emtricitabine Cmax and AUC decreased by 5% and 1%, but Cmin increased by 5%. No effect on the pharmacokinetic parameters of sofosbuvir, GS-331007 or velpatasvir was observed with the combination of emtricitabine, rilpivirine, and tenofovir DF.
Coadministration of emtricitabine (200 mg twice daily with tenofovir-DF and raltegravir) and sofosbuvir/velpatasvir (400/100 mg once daily) increased emtricitabine Cmax, AUC and Cmin by 8%, 5% and 2%, respectively (n=30). No effect on the pharmacokinetic parameters of sofosbuvir, GS-331007 or velpatasvir was observed.
Coadministration of emtricitabine (200 mg once daily with atazanavir, ritonavir and tenofovir-DF) and sofosbuvir/velpatasvir (400/100 mg once daily) was studied in 24 subjects. Cmax and AUC of sofosbuvir increased by 12% and 22%; Cmax, AUC and Cmin of GS-331007 increased by 21%, 32% and 42% respectively. Velpatasvir Cmax, AUC and Cmin increased by 55%, 142%, and 301%. Emtricitabine Cmax, AUC and Cmin increased by 1%, 2% and 6%, respectively. Coadministration of emtricitabine (200 mg once daily with darunavir, ritonavir, and tenofovir-DF) and sofosbuvir/velpatasvir (400/100 mg once daily) was studied in 29 subjects. Cmax and AUC of sofosbuvir decreased by 38% and 28%; Cmax, AUC and Cmin of GS-331007 increased by 4%, 13% and 13% respectively. Velpatasvir Cmax and AUC decreased by 245 and 16%, but Cmin increased by 1%. Emtricitabine Cmax, AUC and Cmin increased by 5%, 5% and 4%, respectively.
Coadministration of emtricitabine (200 once daily with lopinavir, ritonavir and tenofovir-DF) and sofosbuvir/velpatasvir (400/100 mg once daily) was studied in 24 subjects. Cmax and AUC of sofosbuvir decreased by 41% and 29%. Cmax, AUC and Cmin of GS-331007 increased by 1%, 15% and 15%, respectively. Velpatasvir Cmax decreased by 30%, but AUC and Cmin increased by 2% and 63%.