Coadministration has not been studied. Macrogol is not absorbed from the gastro-intestinal tract and is excreted in urine. However, the absorption of other oral medications may be reduced due to increased gastrointestinal transit with macrogol. Do not take macrogol within two hours of taking another oral medication. [Note: this interaction is not specific for sofosbuvir/velpatasvir, but for any oral medication taken with macrogol.]