Coadministration of elbasvir/grazoprevir and CYP3A or P-gp inducers, such as carbamazepine, is contraindicated because it may significantly decrease elbasvir and grazoprevir plasma concentrations and may lead to a reduced therapeutic effect of elbasvir/grazoprevir. The interaction has not been studied but is expected to decrease exposure of elbasvir and grazoprevir due to CYP3A or P-gp induction.

Coadministration is contraindicated. May lead to loss of virologic response to elbasvir/grazoprevir due to significant decreases in elbasvir and grazoprevir plasma concentrations caused by strong CYP3A induction.