Liverpool HEP Interactions

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No Interaction Expected

Sofosbuvir

Lamotrigine

Summary:

Coadministration has not been studied but a clinically significant interaction is unlikely. Lamotrigine is metabolised via UDP-glucuronyl transferases which are not affect by sofosbuvir. Sofosbuvir is a prodrug and formation of its active metabolite is unlikely to be affected by comedications.

Description:

(See Summary)

No Interaction Expected

Sofosbuvir

Lithium

Summary:

Coadministration has not been studied, based on metabolism and clearance a clinically significant pharmacokinetic interaction is unlikely as lithium is almost exclusively renally excreted. Sofosbuvir is a prodrug and formation of its active metabolite is unlikely to be affected by comedications.

Description:

(See Summary)

No Interaction Expected

Sofosbuvir

Methotrexate

Summary:

Coadministration has not been studied, but based on metabolism and clearance a clinically significant pharmacokinetic interaction is unlikely as methotrexate is predominantly eliminated unchanged via the kidneys, with minimal metabolism. Sofosbuvir is a prodrug and formation of its active metabolite is unlikely to be affected by comedications.

Description:

(See Summary)

No Interaction Expected

Sofosbuvir

Quetiapine

Summary:

Coadministration has not been studied but based on metabolism and clearance a clinically significant interaction is unlikely as quetiapine is metabolised by CYP3A4 which is not affected by sofosbuvir. Sofosbuvir is a prodrug and formation of its active metabolite is unlikely to be affected by comedications.

Description:

(See Summary)

No Interaction Expected

Sofosbuvir

Levonorgestrel (IUD)

Summary:

Coadministration with a levonorgestrel intra-uterine device (IUD) has not been studied but there is little potential for an interaction given the local mechanism of action of levonorgestrel. Sofosbuvir is a prodrug and formation of its active metabolite is unlikely to be affected by comedications.

Description:

(See Summary)

No Interaction Expected

Sofosbuvir

Molly (Ecstasy, MDMA)

Summary:

Coadministration has not been studied but based on metabolism and clearance a clinically significant interaction is unlikely as ecstasy is metabolised mainly by CYP2D6 which is not affected by sofosbuvir. Sofosbuvir is a prodrug and formation of its active metabolite is unlikely to be affected by comedications.

Description:

(See Summary)